On the awareness of our inevitable death. The guest is a buddhist who helps terminally ill people to face their fate and has a lot to share.
As Sam puts it so so eloquently in the intro than I can do justice to it, it's not the afterlife and empty promises of endless rewards are what makes this life precious, but that we have only one attempt at it.
https://www.youtube.com/watch?v=es-yJoXEiXA